Sustained oxidative stress causes late acute renal failure via duplex regulation on p38 MAPK and Akt phosphorylation in severely burned rats.
RatBurnScaldSprague-DawleyMalen = n=6 rats per group per time pointTempol and vehicle by intravenous infusion; SB203580, Akt inhibitor IV and tertiary butyl hydroperoxide by intraperitoneal injectionTempol 7.5 mg/ml/kg; SB203580 7.5 mg/ml/kg; Akt inhibitor I…Within 10 minutes after burn
Model: Full-thickness scald burn over 40 per cent of total body surface area by immersion in 100 degrees Celsius water for 15 s, with lactated Ringer resuscitation at 4 ml/kg intraperitoneally immediately and 8 h after burn
Tempol and SB203580 reduced blood urea nitrogen, creatinine, tubular damage score and apoptosis at 72 h after burn, whereas Akt inhibitor IV worsened tubular apoptosis and renal dysfunction, indicating opposing roles for p38 MAPK and Akt.
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