Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice.
MouseRadiationICR (Imprinting Control Region)Femalen = At least 30 mice per experimental group with experiments re…Intraperitoneal injection20 mg/kg or 40 mg/kg as a single dose; continuation regimen…After irradiation, tested from immediately to 240 min post-irradiation, with 15…
Model: Total body X-irradiation at 200 kVp and 20 mA with 0.5 mm aluminium plus 0.5 mm copper filter at about 0.70 Gy/min, using 7.5 Gy for the bone marrow failure model, 5.5 to 7.5 Gy for the dose reduction factor, 7.0 Gy for micronucleus assay, 8.0 Gy for bone marrow pathology and 5.0 Gy for Noxa expression
A single 20 mg/kg intraperitoneal dose 15 min after total body irradiation gave 40.0 per cent 30-day survival versus complete lethality with saline, with 54.5 per cent at 40 mg/kg and 56.7 per cent with the 4-day continuation regimen, a dose reduction factor of about 1.2, improved haemograms and re…
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