Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury.
RatTBIFluid percussionSprague-DawleyMalen = n = 6 per group across 4 groups; microarrays used pooled ne…Not stated for metyrapone or carbenoxolone; saline vehicle given subcutaneouslyMetyrapone 100 mg/kg; carbenoxolone 30 mg/kg30 min before injury (pre-treatment)
Model: Moderate lateral fluid percussion traumatic brain injury at 1.8 to 2.0 atm under isoflurane anaesthesia
Both drugs significantly reduced Fluoro-Jade positive neurons in CA3, without reaching significance in CA1 and CA2, and produced closely similar attenuation of injury-induced cell death, stress and oxidative phosphorylation gene networks.
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