Effect of umbilical cord mesenchymal stem cells on treatment of severe acute pancreatitis in rats.
RatChemical/toxinSprague-DawleyMaleTail vein injection (intravenous)5 x 10^4, 5 x 10^5, 5 x 10^6 or 1 x 10^7 cells/kg0 h, 1 h, 6 h or 12 h after induction of severe acute pancreatitis
Model: Severe acute pancreatitis induced by retrograde pancreatic duct injection of sodium taurocholate
UCMSCs reduced mortality from 58 percent to 10 percent when given at 0 h at 5 x 10^6 cells/kg and reduced ascites, serum amylase, pancreatic oedema and inflammatory cytokines in a time-dependent and dose-dependent manner.
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