Resuscitation with aged blood exacerbates liver injury in a hemorrhagic rat model.
RatHaemorrhage/shockControlledSprague-DawleyMaleIntravenous transfusionAfter acute haemorrhage, as resuscitation
Model: Acute controlled haemorrhage with haemorrhagic shock under anaesthesia
Blood or packed red cells stored for 7 days exacerbated hepatic necrosis and apoptosis and failed to restore liver perfusion, whereas fresh blood significantly improved perfusion, with a five-fold rise in undeformable red cells after 7 days of storage.
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