THERAPY DOSSIER · th-7a48d9dae6b7

Blood resuscitation with fresh blood (day 0), blood stored 4 or 7 days, or packed red blood cells stored 7 days

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02784951 ↗Injury indicationPhase not recordedcompleted

Use of blood and plasma in prehospital haemorrhagic shock (Norwegian HEMS)

Hemorrhagic Shock

Enrolment: 72 · Results not recorded

NCT02724605 ↗PHASE2completed

Intraoperative red blood cell transfusion with different storage duration in paediatric trauma patients

Red Blood Cells Transfusion

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23314580 ↗2013Reported harm

Resuscitation with aged blood exacerbates liver injury in a hemorrhagic rat model.

RatHaemorrhage/shockControlledSprague-DawleyMaleIntravenous transfusionAfter acute haemorrhage, as resuscitation

Model: Acute controlled haemorrhage with haemorrhagic shock under anaesthesia

Blood or packed red cells stored for 7 days exacerbated hepatic necrosis and apoptosis and failed to restore liver perfusion, whereas fresh blood significantly improved perfusion, with a five-fold rise in undeformable red cells after 7 days of storage.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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