The protective effects of sildenafil in acute lung injury in a rat model of severe scald burn: A biochemical and histopathological study.
RatBurnScaldWistarFemalen = 24 rats in 3 equal groupsNot stated10 mg/kg or 20 mg/kgAfter scald injury; exact interval not stated
Model: Severe scald burn covering 30 percent of total body surface area
Sildenafil raised glutathione peroxidase, catalase and total antioxidative capacity, lowered malondialdehyde, total oxidative stress and oxidative stress index and reduced lung inflammation scores, with 10 mg/kg apparently more effective than 20 mg/kg.
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