Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen.
MouseTBIControlled cortical impactBALB/cMalen = 16 mice per group at the start, 8 to 16 analysed per group…Transcranial, non-invasive, probe centred on top of the headFluence 18 J/cm2 at an irradiance of 25 mW/cm2 for 12 min,…First treatment 4 h after injury
Model: Controlled cortical impact through a 5 mm craniotomy over right parietotemporal cortex, 3 mm flat tip, rod speed 4.8 m/s, impact depth 2 mm, targeting a neurological severity score of 7 to 8 at 1 h
Single and especially 3 daily treatments improved neurological severity score and wire grip performance, reduced lesion size and Fluoro-Jade staining and increased bromodeoxyuridine positive cells, whereas 14 daily treatments gave no benefit over injured controls.
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