Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- TBI
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 10
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Sensory-Motor and Cardiorespiratory Rehabilitation Associated With Transcranial Laser Therapy in Patients With Central Nervous System Injury
Post Stroke · Post-Traumatic Headache · Spinal Injuries · Cerebral Palsy, Spastic · Surgery · Sclerosis, Multiple · Spastic
Enrolment: 90 · Results not recorded
Transcranial Photobiomodulation for Executive Function in Bipolar Disorder (TPEB)
Bipolar Disorder
Enrolment: 13 · Results not recorded
Cognitive Enhancement Through Transcranial Laser Therapy
Healthy Participants · Mild Cognitive Impairment
Enrolment: 91 · Results not recorded
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training in the Modification of Pathological Fear
Phobias · Claustrophobia · Social Phobia
Enrolment: 112 · Results not recorded
Efficacy of Transcranial Laser Therapy for Improving Upper Extremity Functional Recovery in Hemiplegic Patients From Ischemic Stroke
Hemiplegia
Enrolment: 25 · Results not recorded
Revitalize Cognition: A Proof of Concept Study Using Transcranial Near Infrared Stimulation in Older Adults
Aging
Enrolment: 16 · Results not recorded
A Longitudinal Study Investigating the Effects of Photobiomodulation (PBM) on Cognitive Function and AD-Related Biomarkers in Individuals With MCI or Dementia Due to AD
Alzheimer's Disease
Enrolment: 45 · Results not recorded
Efficacy of Photobiomodulation on Core Symptoms of Autism
Autism
Enrolment: 30 · Results not recorded
Brain Vascular and Neurocognitive Health
Cognitive Decline · Cognitive Dysfunction · Alzheimer Disease · Vascular Disease, Peripheral
Enrolment: 24 · Results not recorded
Photobiomodulation Radiant Intervention for Stress in Epilepsy
Epilepsy
Enrolment: 80 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseTBIControlled cortical impactBALB/cMalen = 16 mice per group at the start, 8 to 16 analysed per group…Transcranial, non-invasive, probe centred on top of the headFluence 18 J/cm2 at an irradiance of 25 mW/cm2 for 12 min,…First treatment 4 h after injury
Model: Controlled cortical impact through a 5 mm craniotomy over right parietotemporal cortex, 3 mm flat tip, rod speed 4.8 m/s, impact depth 2 mm, targeting a neurological severity score of 7 to 8 at 1 h
Single and especially 3 daily treatments improved neurological severity score and wire grip performance, reduced lesion size and Fluoro-Jade staining and increased bromodeoxyuridine positive cells, whereas 14 daily treatments gave no benefit over injured controls.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.