Lacosamide improves outcome in a murine model of traumatic brain injury.
MouseTBIClosed-head / concussionC57BL/6MaleNot statedLow dose 6 mg/kg or high dose 30 mg/kgFirst dose 30 min after injury
Model: Moderate closed head injury using a pneumatic impactor
High-dose lacosamide improved rotarod and Morris water maze performance, reduced neuronal injury at 24 h and microglial activation at 7 days and delayed injury-related inflammatory gene expression, but did not increase neuronal density at 31 days.
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