Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin.
RatOtherSprague-DawleyFemalen = 168 animals in total; oxytocin n = 7, saline n = 6, atosiba…Intrathecal by acute puncture between the L3 and L4 vertebrae120 ng in 10 microlitresGiven on day 22 after delivery, one day after separation from pups; spinal nerv…
Model: Spinal nerve ligation with tight ligation of the right L5 and L6 spinal nerves under isoflurane anaesthesia
Hypersensitivity after spinal nerve ligation partially resolved in the postpartum period only while pups were present, cerebrospinal fluid oxytocin was higher in postpartum rats before weaning, intrathecal oxytocin reversed hypersensitivity after separation from pups, and intrathecal atosiban but n…
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