Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats.
RatCrushLimb / muscle crushSprague-DawleyMaleIntravenous infusion added to normal saline resuscitation fluid10 mg/kg per hourFluid resuscitation with sivelestat started 1 h before release of compression
Model: Crush injury by 6 h direct compression of both hindlimbs with 3.5 kg blocks on each side, followed by 3 h of reperfusion
Sivelestat significantly improved survival (p = 0.032) and was accompanied by lower serum high-mobility group box 1, attenuated lung injury on histology, and suppressed high-mobility group box 1 expression in lung and liver.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.