Comparative study between bone marrow mononuclear fraction and mesenchymal stem cells treatment in sensorimotor recovery after focal cortical ablation in rats.
RatTBIUnspecifiedWistarMalen = MSCs n=8, BMMCs n=9, vehicle control n=18, plus 4 additiona…Intravenous, via the left jugular vein24 hours after ablation
Model: Focal cortical ablation by aspiration of all six cortical layers of the left frontoparietal cortex (+2 to -6 mm anteroposterior from bregma) under ketamine 90 mg/kg and xylazine 10 mg/kg intraperitoneal anaesthesia, with a collagen haemostatic sponge placed in the lesion
Both MSCs and BMMCs produced significant sensorimotor recovery relative to vehicle controls in the cylinder test and, from post-ablation day 35 onwards, in the adhesive removal test. The two cell types were broadly equivalent, except at day 91 when BMMC-induced recovery was significantly greater on…
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