Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells
Traumatic Brain Injury
Enrolment: 25 · Results not recorded
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Biologic
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Traumatic Brain Injury
Enrolment: 25 · Results not recorded
Liver Cirrhosis, Biliary
Enrolment: 17 · Results not recorded
Chronic Hepatitis · Hepatic Cirrhosis
Enrolment: 30 · Results not recorded
Peripheral Vascular Diseases · Diabetic Foot
Enrolment: 20 · Results not recorded
Chronic Limb-threatening Ischemia · Diabetes Mellitus
Enrolment: 24 · Results not recorded
Type 2 Diabetes Mellitus
Enrolment: 60 · Results not recorded
Old Myocardial Infarction · Chronic Myocardial Ischemia · Left Ventricular Dysfunction
Enrolment: 60 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Focal cortical ablation by aspiration of all six cortical layers of the left frontoparietal cortex (+2 to -6 mm anteroposterior from bregma) under ketamine 90 mg/kg and xylazine 10 mg/kg intraperitoneal anaesthesia, with a collagen haemostatic sponge placed in the lesion
Both MSCs and BMMCs produced significant sensorimotor recovery relative to vehicle controls in the cylinder test and, from post-ablation day 35 onwards, in the adhesive removal test. The two cell types were broadly equivalent, except at day 91 when BMMC-induced recovery was significantly greater on…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.