Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice.
MouseChemical/toxinC57BLMaleOral administrationAfter carbon tetrachloride injection
Model: Carbon tetrachloride-induced acute liver injury and acute liver failure
Baicalein given orally after carbon tetrachloride conferred a survival benefit, raised hepatic IL-6 and TNF-alpha within 12 hours and lowered them at 24, 48 and 72 hours relative to control. TGF-alpha, HGF and EGF expression increased markedly at all time points, consistent with accelerated liver r…
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