Anti-inflammatory effects of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury model.
MouseEndotoxin/LPSBALB/cMale
Model: Lipopolysaccharide-induced acute lung injury, with parallel in vitro lipopolysaccharide-stimulated RAW 264.7 macrophage experiments
Linalool attenuated lipopolysaccharide-induced tumour necrosis factor alpha and interleukin-6 production both in vitro and in vivo, blocked phosphorylation of IkB alpha and mitogen-activated protein kinases in stimulated macrophages, and attenuated lung histopathological changes in mice.
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