Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats.
RatTBIControlled cortical impactSprague-DawleyMalen = 90 adult male rats allocated across six injured and six sha…Intraperitoneal0.25, 0.5, 1.0, 2.0 or 3.0 mg/kgTreatment began 24 hours after surgery
Model: Controlled cortical impact, 2.8 mm cortical depth at 4 m/s in anaesthetised rats (moderate injury), with sham injury as control
None of the five donepezil doses improved motor or cognitive function relative to vehicle-treated injured controls. The two highest doses were detrimental, significantly impairing beam balance at 3.0 mg/kg, beam walk at 2.0 and 3.0 mg/kg and cognitive performance at 3.0 mg/kg.
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