Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain
Neuropathic Pain
Enrolment: 5 · Results not recorded
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Drug · Acetylcholinesterase inhibitor
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Neuropathic Pain
Enrolment: 5 · Results not recorded
Dementia, Alzheimer Type
Enrolment: 64 · Results not recorded
Mild Alzheimer Disease
Enrolment: 312 · Results not recorded
Alzheimer's Disease
Enrolment: 186 · Results not recorded
Alzheimer Type Dementia
Enrolment: 280 · Results not recorded
Parkinson Disease · Mild Cognitive Impairment
Enrolment: 120 · Results not recorded
Alzheimer's Disease
Enrolment: 500 · Results not recorded
Alzheimer's Disease
Enrolment: 18 · Results not recorded
Alzheimer's Disease
Enrolment: 38 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Controlled cortical impact, 2.8 mm cortical depth at 4 m/s in anaesthetised rats (moderate injury), with sham injury as control
None of the five donepezil doses improved motor or cognitive function relative to vehicle-treated injured controls. The two highest doses were detrimental, significantly impairing beam balance at 3.0 mg/kg, beam walk at 2.0 and 3.0 mg/kg and cognitive performance at 3.0 mg/kg.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.