The role of interferon-gamma inducible protein-10 in a mouse model of acute liver injury post induced pluripotent stem cells transplantation.
MouseChemical/toxinC57/B6n = ALT/AST n=6; necrotic area n=5; proliferation n=6; hepatic…iPS and iHL by tail vein (intravenous); anti-IP-10 antibody and BrdU intraperitonealAnti-IP-10 antibody 0.5 micrograms per dose; recombinant IP…Cells and recombinant IP-10 given 4 hours after injury; anti-IP-10 antibody giv…
Model: Acute liver injury from a single intraperitoneal dose of carbon tetrachloride in mineral oil at 0.35 microlitres per gram; a repetitive injury model gave carbon tetrachloride at 0, 24 and 48 hours for the 72 hour survival study
Intravenous iPS reduced serum ALT and AST at 24 and 36 hours, cut necrotic area by about 40 per cent, more than doubled proliferating hepatocytes at 48 hours and raised hepatic IP-10, whereas iHL lowered transaminases but did not significantly reduce necrosis. Recombinant IP-10 reproduced the prote…
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