THERAPY DOSSIER · th-8b1327e1a87f

Mouse induced pluripotent stem cells (iPS), iPS-derived hepatocyte-like cells (iHL), recombinant IP-10 (CXCL10) and an anti-IP-10 neutralising antibody

Biologic · Cell therapy (iPS-derived hepatocyte-like cells); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Cell therapy (iPS-derived hepatocyte-like cells); not a ChEMBL entity
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07312864 ↗PHASE1/PHASE2recruiting

Bioartificial Liver Therapy Using Chemically Induced Pluripotent Stem Cells in Liver Failure

Liver Failure

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23227188 ↗2012Mixed findings

The role of interferon-gamma inducible protein-10 in a mouse model of acute liver injury post induced pluripotent stem cells transplantation.

MouseChemical/toxinC57/B6n = ALT/AST n=6; necrotic area n=5; proliferation n=6; hepatic…iPS and iHL by tail vein (intravenous); anti-IP-10 antibody and BrdU intraperitonealAnti-IP-10 antibody 0.5 micrograms per dose; recombinant IP…Cells and recombinant IP-10 given 4 hours after injury; anti-IP-10 antibody giv…

Model: Acute liver injury from a single intraperitoneal dose of carbon tetrachloride in mineral oil at 0.35 microlitres per gram; a repetitive injury model gave carbon tetrachloride at 0, 24 and 48 hours for the 72 hour survival study

Intravenous iPS reduced serum ALT and AST at 24 and 36 hours, cut necrotic area by about 40 per cent, more than doubled proliferating hepatocytes at 48 hours and raised hepatic IP-10, whereas iHL lowered transaminases but did not significantly reduce necrosis. Recombinant IP-10 reproduced the prote…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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