Does presoaking synthetic mesh in antibiotic solution reduce mesh infections? An experimental study.
Model: Acute clean-contaminated ventral hernia repair with one of four synthetic meshes (composite multifilament polyester Parietex PCO, multifilament polyester Parietex TET, composite monofilament polypropylene Ventralight, monofilament polypropylene SoftMesh), contaminated after implantation with 10^4 colony-forming units of methicillin-resistant Staphylococcus aureus
Presoaking in vancomycin significantly improved MRSA clearance for composite and multifilament polyester meshes: Parietex PCO 0 versus 56 per cent (p=0.006), Parietex TET 0 versus 50 per cent (p=0.01) and Ventralight 20 versus 78 per cent (p=0.012). There was no significant benefit for monofilament…
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