THERAPY DOSSIER · th-e7779a2c0999

Vancomycin, applied as a mesh presoak

Drug · Peptidoglycan inhibitor

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Peptidoglycan inhibitor
Target: Peptidoglycan
Injury models: Wound
Reported indication: Not recorded
First approval: 1964
Development stage: Not recorded
ChEMBL record: CHEMBL262777 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Vancomicina; Vancomycin; Vancomycine
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00138112 ↗PHASE3completed

Randomized Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Early Viridans Streptococcal Sepsis After Hematopoietic Cell Transplantation

Streptococcal Sepsis · Hematologic Malignancies

Enrolment: 126 · Results not recorded

NCT01720940 ↗NAunknown

Reducing Nephrotoxicity of Vancomycin: Continuous Versus Intermittent Infusion of Vancomycin

Infections Requiring Prolonged Duration (>10 Days) of Vancomycin

Enrolment: 220 · Results not recorded

NCT01157533 ↗NAterminated

Utility of Vancomycin Loading: A Pharmacokinetic Analysis in Critically Ill Patients

Infection

Enrolment: 1 · Results not recorded

NCT02241421 ↗NAcompleted

The Effect of the Knock Down of Gut Microbiota by Antibiotics on Parameters of Body Weight Control and Insulin Sensitivity

Obesity · Insulin Resistance

Enrolment: 57 · Results not recorded

NCT06383611 ↗Phase not recordedtemporarily not available

Expanded Access to Cyclic Irrigation of Vancomycin Hydrochloride and Tobramycin Sulfate in Exchange Arthroplasty for Periprosthetic Joint Infection

Prosthetic-joint Infection

Enrolment not recorded · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23212529 ↗2012Mixed findings

Does presoaking synthetic mesh in antibiotic solution reduce mesh infections? An experimental study.

RatWoundMaleMesh presoak before implantation10 mg/mL vancomycin solutionBefore implantation and bacterial contamination

Model: Acute clean-contaminated ventral hernia repair with one of four synthetic meshes (composite multifilament polyester Parietex PCO, multifilament polyester Parietex TET, composite monofilament polypropylene Ventralight, monofilament polypropylene SoftMesh), contaminated after implantation with 10^4 colony-forming units of methicillin-resistant Staphylococcus aureus

Presoaking in vancomycin significantly improved MRSA clearance for composite and multifilament polyester meshes: Parietex PCO 0 versus 56 per cent (p=0.006), Parietex TET 0 versus 50 per cent (p=0.01) and Ventralight 20 versus 78 per cent (p=0.012). There was no significant benefit for monofilament…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

Loading the evidence…