Human mesenchymal stem cells reduce lung injury in immunocompromised mice but not in immunocompetent mice.
MouseChemical/toxinSCID (immunocompromised) and C57Bl/6 (immunocompetent)FemaleIntravenousOne million human mesenchymal stem cells24 hours after induction of bleomycin lung injury
Model: Bleomycin-induced lung injury from a single bolus intranasal instillation of bleomycin
Human mesenchymal stem cell xenotransplantation produced transient improvement in lung weight and tidal volume and persistent improvement in inspiratory duty cycle, inspiratory flow rate and inspiration to expiration ratio in SCID mice, with reduced Ashcroft scores, collagen deposition and inflamma…
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