Reduction of brain edema and expression of aquaporins with acute ethanol treatment after traumatic brain injury.
RatTBIWeight-drop / impact-accelerationSprague-DawleyMaleIntraperitoneal injection0.5 g/kg or 1.5 g/kg60 minutes after traumatic brain injury
Model: Closed head impact-acceleration traumatic brain injury using the Marmarou method
Ethanol given 60 minutes after traumatic brain injury significantly reduced brain water content and aquaporin mRNA and protein expression compared with untreated injury. Treated animals also showed significantly faster radial maze completion times and improved motor coordination.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.