Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.
MouseRadiationC57BL/6MaleAfter cranial irradiation
Model: Brain-focused cranial irradiation in juvenile mice as a model of radiation-induced brain injury
Lithium stimulated brain progenitor cell proliferation and differentiation and prevented oligodendrocyte loss in the dentate gyrus after cranial irradiation. Am80 reduced cyclooxygenase-2 positive microglial cells but did not enhance lithium-induced neurogenesis recovery, and lithium was superior t…
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