Aripiprazole With Lithium or Valproate in Long-Term Maintenance of Bipolar I Disorder
Bipolar Disorder
Enrolment: 1270 · Results not recorded
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Drug · Inhibitor of inositol monophosphatase 1 (IMPA1) and of glycogen synthase kinase-3
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Bipolar Disorder
Enrolment: 1270 · Results not recorded
Mild Cognitive Impairment
Enrolment: 83 · Results not recorded
Bipolar Depression
Enrolment: 60 · Results not recorded
Bipolar I Disorder
Enrolment: 710 · Results not recorded
Long COVID
Enrolment: 52 · Results not recorded
Bipolar Depression
Enrolment: 0 · Results not recorded
Bipolar Disorder
Enrolment: 98 · Results not recorded
Inclusion Body Myositis
Enrolment: 20 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: 200 rad whole-body irradiation producing haematopoietic injury
Lithium increased granulopoietic recovery with significant elevations in marrow and spleen derived CFU-GM compared with irradiated controls, and a significant elevation in white cell count consisting mainly of neutrophils. Erythroid stem cells (CFU-E, BFU-E) and iron-59 incorporation were slightly…
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Model: Cold-induced (cryogenic) traumatic brain injury
Both prophylactic and acute lithium reduced infarct volume and apoptosis, and high dose lithium was the most mobile group on tail suspension testing with significantly reduced infarct volume at subacute follow-up. However, hippocampal atrophy occurred in both lithium groups and was significant bila…
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Model: Permanent distal middle cerebral artery occlusion combined with transient bilateral common carotid artery occlusion, modelling stroke with partial reperfusion
A bolus of lithium at stroke onset robustly reduced infarct size at 48 h and inhibited cell death in the ischaemic penumbra but not the core at 24 h, without altering Akt activity, phosphorylated GSK3beta or beta-catenin degradation.
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Model: Stereotaxic infusion of collagenase into the left basal ganglia to induce intracerebral haemorrhage
Lithium pretreatment improved behavioural recovery at 2 days and reduced hemispheric swelling at 3 days and hemispheric atrophy at 42 days, without altering hematoma volume. Perihaematomal cell death, cyclooxygenase-2 expression and reactive microglia were all reduced.
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Model: Brain-focused cranial irradiation in juvenile mice as a model of radiation-induced brain injury
Lithium stimulated brain progenitor cell proliferation and differentiation and prevented oligodendrocyte loss in the dentate gyrus after cranial irradiation. Am80 reduced cyclooxygenase-2 positive microglial cells but did not enhance lithium-induced neurogenesis recovery, and lithium was superior t…
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.