Atrial natriuretic peptide attenuates agonist-induced pulmonary edema in mice with targeted disruption of the gene for natriuretic peptide receptor-A.
MouseEndotoxin/LPSNatriuretic peptide receptor-A wild-type, heterozygous and knockout miceInfusionPretreatment before agonist challenge
Model: Acute lung injury and pulmonary oedema induced in anaesthetised mice by thrombin receptor agonist peptide or lipopolysaccharide, with in vitro thrombin-induced loss of transmembrane electrical resistance in pulmonary microvascular endothelial cell monolayers
Pretreatment with atrial natriuretic peptide completely blocked thrombin receptor agonist peptide induced increases in lung wet-to-dry weight and blunted lipopolysaccharide induced increases in lavage cell counts and protein in both NPR-A knockout and wild-type mice. The NPR-C specific ligand cANF…
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