TGF-beta1 expression in wound healing is acutely affected by experimental malnutrition and early enteral feeding.
RatWoundLewisMalen = Malnourished n=27 and eutrophic control n=30Enteral, via gastrostomy; control animals received oral chow and salineIsocaloric and isonitrogenous regimens; exact quantities no…Early enteral feeding after wounding, with analysis on post-trauma day 7
Model: Standardised cutaneous dorsal wounds with gastrostomies for enteral feeding, created in malnourished and eutrophic control rats
Malnourished chow-fed rats had significantly lower TGF-beta1 mRNA in granulation tissue than eutrophic controls (2.58 plus or minus 0.83 versus 3.53 plus or minus 0.57, p<0.01) and than malnourished rats given standard or supplemented enteral diets (4.66 plus or minus 2.49 and 4.61 plus or minus 2.…
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