THERAPY DOSSIER · th-be37eb52706c

Early enteral feeding with a standard enteral diet or a diet supplemented with arginine and antioxidants

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23194083 ↗2012Reported benefit

TGF-beta1 expression in wound healing is acutely affected by experimental malnutrition and early enteral feeding.

RatWoundLewisMalen = Malnourished n=27 and eutrophic control n=30Enteral, via gastrostomy; control animals received oral chow and salineIsocaloric and isonitrogenous regimens; exact quantities no…Early enteral feeding after wounding, with analysis on post-trauma day 7

Model: Standardised cutaneous dorsal wounds with gastrostomies for enteral feeding, created in malnourished and eutrophic control rats

Malnourished chow-fed rats had significantly lower TGF-beta1 mRNA in granulation tissue than eutrophic controls (2.58 plus or minus 0.83 versus 3.53 plus or minus 0.57, p<0.01) and than malnourished rats given standard or supplemented enteral diets (4.66 plus or minus 2.49 and 4.61 plus or minus 2.…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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