Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury.
MouseBurnScaldC57BL/6maleIntraperitoneal injection for IL-22; oral gavage for ethanolIL-22 1 mg/kg; ethanol 2.9 mg/kg as stated in the abstractImmediately after burn injury
Model: Acute ethanol intoxication by gavage followed by a full-thickness scald burn of approximately 12.5% total body surface area
IL-22 treatment normalised intestinal Reg3β and Reg3γ expression and attenuated the rise in intestinal permeability after combined ethanol and burn injury, and reduced bacterial load in about half of treated mice.
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