Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model.
RatTBIUnspecifiedSprague-DawleymaleSystemic surface and body coolingHead and body temperature reduced to 33 degrees CEarly group cooled 30 minutes before craniotomy; late group cooled 30 minutes a…
Model: Acute subdural haematoma with craniotomy and surgical decompression in rats
Early preoperative hypothermia lowered extracellular UCH-L1 (4.9 plus or minus 1.0 versus 50.2 plus or minus 28.3 ng/dl) and GFAP, reduced Fluoro-Jade B-positive cells (180,903 plus or minus 42,212 versus 774,588 plus or minus 162,173) and reduced injury volume (115.2 plus or minus 15.4 versus 311.…
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