THERAPY DOSSIER · th-d9e6013659c0

Mild therapeutic hypothermia (33 degrees C)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04545424 ↗PHASE2recruiting

Cooling to Help Injured Lungs (CHILL) Phase IIB Randomized Control Trial of Therapeutic Hypothermia in Patients With ARDS

Respiratory Distress Syndrome, Adult

Enrolment: 340 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23140154 ↗2012Reported benefit

Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model.

RatTBIUnspecifiedSprague-DawleymaleSystemic surface and body coolingHead and body temperature reduced to 33 degrees CEarly group cooled 30 minutes before craniotomy; late group cooled 30 minutes a…

Model: Acute subdural haematoma with craniotomy and surgical decompression in rats

Early preoperative hypothermia lowered extracellular UCH-L1 (4.9 plus or minus 1.0 versus 50.2 plus or minus 28.3 ng/dl) and GFAP, reduced Fluoro-Jade B-positive cells (180,903 plus or minus 42,212 versus 774,588 plus or minus 162,173) and reduced injury volume (115.2 plus or minus 15.4 versus 311.…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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