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PRECLINICAL PUBLICATION · 2012

nNOS expression in the brain of rats after burn and the effect of the ACE inhibitor captopril.

Rat / Burn

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 23137627 ↗2012Mixed findings

nNOS expression in the brain of rats after burn and the effect of the ACE inhibitor captopril.

RatBurnScaldWistar albinomaleIntraperitoneal10 mg/kgImmediately after burn

Model: Dorsal scald burn produced by exposure to 90 degrees C water for 10 s (sham 25 degrees C)

Burn increased nNOS expression in frontal cortex, striatum and midbrain; captopril reduced nNOS in frontal cortex and midbrain but increased striatal and hippocampal nNOS relative to control.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.