Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
MouseRadiationC57BL/6malePretreatment before total body irradiation
Model: Total body irradiation causing acute bone marrow syndrome and long-term haematopoietic stem cell injury
Resveratrol pretreatment protected mice from acute bone marrow syndrome and lethality and ameliorated long-term bone marrow injury by reducing haematopoietic stem cell reactive oxygen species and senescence, an effect attenuated by the Sirt1 inhibitor Ex527.
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