Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG).
MouseRadiationC57BL/6Femalen = n = 15 per non-irradiated cohort and n = 25 per irradiated…Oral, in diet10% or 20% flaxseed lignan complex diet, equal to 0.337% an…Started 3 weeks before irradiation
Model: Single fraction thoracic X irradiation 13.5 Gy causing radiation pneumonopathy; orthotopic Lewis lung carcinoma arm at 15 Gy
Lignan complex improved survival by roughly a third, cut lavage leucocytes and neutrophils, preserved oxygen saturation and lowered fibrosis without protecting tumour.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.