THERAPY DOSSIER · th-f86eb0b12d5f

Flaxseed lignan complex enriched in secoisolariciresinol diglucoside

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00204412 ↗PHASE3completed

Effectiveness of Flax Lignan and Exercise Training for Improving Lipid Profiles

Metabolic Syndrome · Osteoporosis

Enrolment: 100 · Results not recorded

NCT01276704 ↗PHASE2terminated

Flaxseed Lignan as a Prevention Strategy for Pre-Menopausal Women at High Risk for Breast Cancer

Breast Cancer

Enrolment: 180 · Results not recorded

NCT01234506 ↗PHASE2completed

Oxidative Stress and Nutritional Supplementation Intervention Study (SDG)

Oxidative Stress · Inflammation · Aging · Dementia · Pain

Enrolment: 21 · Results not recorded

NCT02391779 ↗PHASE2completed

Flaxseed Lignan Enriched Complex for Blood Pressure Reduction in Elderly Participants

Hypertension

Enrolment: 100 · Results not recorded

NCT01531569 ↗PHASE2completed

Single Oral Dose of BeneFlax (38% SDG) to Healthy Young and Older Adults

Diabetes Mellitus, Type 2 · Hypercholesterolemia

Enrolment: 22 · Results not recorded

NCT01846117 ↗PHASE1/PHASE2completed

Once-Daily Oral Dose of BeneFlax to Healthy Older Adults

Oxidative Stress · Inflammation · Aging · Pain

Enrolment: 32 · Results not recorded

NCT01396369 ↗EARLY_PHASE1completed

Impact of Flaxseed Lignan (Brevail) on Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome

Enrolment: 9 · Results not recorded

NCT01314586 ↗NAcompleted

Iowa State Study on Flax Lignans and Heart Health

Hypercholesterolemia

Enrolment: 93 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23106213 ↗2012Reported benefit

Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG).

MouseRadiationC57BL/6Femalen = n = 15 per non-irradiated cohort and n = 25 per irradiated…Oral, in diet10% or 20% flaxseed lignan complex diet, equal to 0.337% an…Started 3 weeks before irradiation

Model: Single fraction thoracic X irradiation 13.5 Gy causing radiation pneumonopathy; orthotopic Lewis lung carcinoma arm at 15 Gy

Lignan complex improved survival by roughly a third, cut lavage leucocytes and neutrophils, preserved oxygen saturation and lowered fibrosis without protecting tumour.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Loading the evidence…