Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist.
MouseRadiationC57BL/6JMalen = 41 mice: 10 mock, 10 low dose, 11 high dose, 10 amifostineIntraperitoneal5 mg/kg low dose or 10 mg/kg high dose30 minutes before irradiation
Model: Single 8 Gy cobalt-60 gamma ray total body irradiation
Thirty day survival was 50% at the low dose and 64% at the high dose versus 0% in irradiated controls, with body weight maintained.
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