THERAPY DOSSIER · th-9083dba240cd

Branched polyethylenimine, approximately 25 kDa

Drug · Cationic polymer; no confident ChEMBL small-molecule entity (polymeric agent).

Evidence & regulatory context

Mechanism: Cationic polymer; no confident ChEMBL small-molecule entity (polymeric agent).
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: PEI; Polyethyleneimine; Branched PEI 25 kDa
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01167985 ↗PHASE2unknown

Antibacterial Effect of Insoluble Antibacterial Nanoparticles (quaternary ammonium polyethylenimine) in Endodontic Materials

Endodontic Treatment · Irreversible Pulpitis

Enrolment: 200 · Results not recorded

NCT03739138 ↗PHASE1terminated

Intratumoral MK-4621/JetPEI (polyethylenimine-formulated RNA) as monotherapy or with pembrolizumab in advanced solid tumours

Advanced Solid Tumors

Enrolment: 30 · Results not recorded

NCT01948778 ↗NAcompleted

Polyethyleneimine-coated membrane (oXiris) for haemofiltration versus polymyxin B-immobilised fibre column in septic shock

Patients in Septic Shock

Enrolment: 38 · Results not recorded

NCT00299598 ↗Phase not recordedcompleted

Safety and Efficacy of Antibacterial Nano Particles (alkylated polyethylenimine) Incorporated in Dental Composite

Oral Health

Enrolment: 10 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23104900 ↗2012Reported benefit

Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist.

MouseRadiationC57BL/6JMalen = 41 mice: 10 mock, 10 low dose, 11 high dose, 10 amifostineIntraperitoneal5 mg/kg low dose or 10 mg/kg high dose30 minutes before irradiation

Model: Single 8 Gy cobalt-60 gamma ray total body irradiation

Thirty day survival was 50% at the low dose and 64% at the high dose versus 0% in irradiated controls, with body weight maintained.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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