Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-kappaB signaling pathway in rodents.
MixedEndotoxin/LPSSprague-Dawley ratsMaleIntravenous in rats; intraperitoneal in mice15 mg/kg intravenous in rats; 60 mg/kg intraperitoneal in m…1 h or 6 h after lipopolysaccharide challenge
Model: Lipopolysaccharide induced acute lung injury and endotoxaemia
Post-treatment at 1 h or 6 h reduced lung injury, TNF-alpha, nitric oxide, NF-kappaB activation and HMGB1 release, and improved survival.
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