Amelioration of paraquat-induced pulmonary injury by mesenchymal stem cells.
RatChemical/toxinSprague-DawleyMale6 h after paraquat exposure
Model: Acute paraquat poisoning with lung injury induced by intraperitoneal paraquat 24 mg/kg body weight; in vitro rat type II pneumocyte L2 cells exposed to 0.5 mM paraquat
Mesenchymal stem cell transplantation 6 h after paraquat exposure reduced deterioration of liver and renal function, alleviated lung injury and prolonged survival, with coculture showing reduced paraquat accumulation and increased antioxidative gene expression in type II pneumocytes.
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