Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22.
RatChemical/toxinSprague-DawleyMalen = 72 rats randomised across three groups; per-group numbers n…50 mg/kg30 min before induction of pancreatitis
Model: Severe acute pancreatitis with associated lung injury induced by infusion of 1 mL/kg sodium taurocholate 4 per cent solution into the biliopancreatic duct
Melatonin given 30 min before taurocholate-induced severe acute pancreatitis lowered pancreatic pathological scores at all time points and restored lung interleukin 22 and T helper 22 mRNA levels relative to untreated animals.
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