Proresolution therapy for the treatment of delayed healing of diabetic wounds.
MouseWoundB6.BKS(D)-Lepr(db)/J (db/db) and wild-type C57BL/6JMalen = Wound closure n=5 to 9; granulation tissue area and Fpr2 n=…Topical application to the wound bed plus four intradermal injections of 10 microlitres per site; retro-orbital injection in the thymocyte modelWounds, 100 ng in 50 microlitres per wound per day; thymocy…Wounds, first dose 24 h after wounding; peritonitis, 32 h after zymosan with ex…
Model: Two 5 mm full-thickness excisional dorsal skin wounds with silicone splinting to prevent contraction; secondary models of zymosan A-induced peritonitis at 0.04 mg/g intraperitoneally and dexamethasone-induced thymocyte apoptosis at 15 mg/kg intraperitoneally
Local resolvin D1 accelerated closure of splinted cutaneous wounds in diabetic db/db mice, with smaller wound diameter by day 8, more granulation tissue and fewer apoptotic cells and CD68-positive macrophages than vehicle.
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