Radioprotective properties of tocopherol succinate against ionizing radiation in mice.
MouseRadiationCD2F1Malen = 8 mice per treatment group with 6 sections per mouse for hi…Subcutaneous400 mg/kg in 0.1 mL of polyethylene glycol-400 plus Tween-8024 h before irradiation
Model: Whole body bilateral cobalt-60 gamma irradiation at 0.6 Gy/min; 11 Gy for jejunal histology and immunohistochemistry endpoints and 9.2 Gy for the comet assay
Subcutaneous tocopherol succinate given 24 h before lethal gamma irradiation reduced jejunal CD68-positive inflammatory cells, DNA damage in blood, spleen and thymus cells and apoptotic markers, while increasing phospho-histone H3 and proliferating cell nuclear antigen positive crypt cells.
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