The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.
RatTBIUnspecifiedWistarMalen = Vehicle n=10; diazoxide n=9; diazoxide plus 5-hydroxydecano…Intraventricular15 min before induction of subdural haematoma
Model: Acute subdural haematoma produced by subdural infusion of 400 microlitres of autologous venous blood
Intraventricular diazoxide before acute subdural haematoma significantly reduced infarct volume and brain oedema, and this protection was abolished by co-treatment with 5-hydroxydecanoate, while 5-hydroxydecanoate alone increased infarct volume.
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