PRECLINICAL PUBLICATION · 2012

Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Mesenchymal stem cell-derived conditioned medium, with whole mesenchymal stem cells and recombinant insulin-like growth factor I tested separately

PMID 23023971 ↗2012Reported benefit

Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action.

MouseEndotoxin/LPSC57BL/6MaleIntratracheal

Model: Lipopolysaccharide-induced acute lung injury

Intratracheal mesenchymal stem cells and their conditioned medium attenuated lipopolysaccharide-induced neutrophil influx, lung oedema and injury score and shifted alveolar macrophages towards an M2 phenotype, with recombinant insulin-like growth factor I partly reproducing the protection.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.