THERAPY DOSSIER · th-7d44f8f38035

Mesenchymal stem cell-derived conditioned medium, with whole mesenchymal stem cells and recombinant insulin-like growth factor I tested separately

Biologic · Cell-derived secretome product; no confident ChEMBL small-molecule entity.

Evidence & regulatory context

Mechanism: Cell-derived secretome product; no confident ChEMBL small-molecule entity.
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: MSC-CM; MSC conditioned medium; MSC secretome
Note: Not recorded

Clinical trials 3

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04235296 ↗Injury indicationPHASE1unknown

Safety and Effectiveness of Mesenchymal Stem Cell Conditioned Medium-derived Pleiotropic Factor in Treating Residual Burn Wound

Residual Burn Wound

Enrolment: 30 · Results not recorded

NCT04326959 ↗PHASE1/PHASE2unknown

Implantation of Mesenchymal Stem Cell, Conditioned Medium, or Triamcinolone Acetonide for Keloid Regression

Keloid

Enrolment: 24 · Results not recorded

NCT04234750 ↗PHASE1unknown

Safety and Effectiveness of Mesenchymal Stem Cell-derived Pleiotropic Factor in the Treatment of Donor Sites

Skin Graft Donor Sites

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23023971 ↗2012Reported benefit

Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action.

MouseEndotoxin/LPSC57BL/6MaleIntratracheal

Model: Lipopolysaccharide-induced acute lung injury

Intratracheal mesenchymal stem cells and their conditioned medium attenuated lipopolysaccharide-induced neutrophil influx, lung oedema and injury score and shifted alveolar macrophages towards an M2 phenotype, with recombinant insulin-like growth factor I partly reproducing the protection.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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