17beta-Estradiol reappropriates mass lost to the hypermetabolic state in thermally injured rats.
RatBurnScaldSprague-DawleyMalen = 12 male rats randomly assigned across three groups; per-gro…Subcutaneous0.5 mg/kg15 min after the burn injury
Model: 40 per cent total body surface area full-thickness scald burn by immersion of the back and flank in water at 100 degrees Celsius for 10 seconds, with sham animals immersed in room-temperature water, followed by Parkland formula resuscitation of 4 mL/kg per percent burn of lactated Ringer solution intraperitoneally, half immediately and half over 8 h
A single subcutaneous dose of 17beta-estradiol given 15 min after a 40 per cent total body surface area scald burn spared body mass during the first two weeks and improved the recovery phase, but fasting glucose and insulin did not differ from vehicle.
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