Human mesenchymal precursor cells (Stro-1+) from spinal cord injury patients improve functional recovery and tissue sparing in an acute spinal cord injury rat model.
RatSpinal cord injuryContusionRNU nude (athymic, T-cell deficient)FemaleIntraspinal transplantation as a suspension graft into the injured spinal cordAcutely after contusive spinal cord injury
Model: Acute moderate contusive spinal cord injury with transplantation of a cell suspension graft into the injured cord
Transplanted animals showed statistically significant improvement in functional recovery, tissue sparing and cyst reduction, reaching mean BBB scores of 15 at 8 weeks, with increased 5-HT and CGRP axonal growth around the graft, although retrograde tracing showed no significant difference from cont…
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