THERAPY DOSSIER · th-031ff5b10210

Stro-1+ selected human mesenchymal precursor cells (hMPCs) isolated from bone marrow stroma of spinal cord injury patients

Biologic · Cell therapy (Stro-1+ mesenchymal precursor cells); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Cell therapy (Stro-1+ mesenchymal precursor cells); not a ChEMBL entity
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02412735 ↗PHASE3completed

Rexlemestrocel-L (mesenchymal precursor cells) Alone or With HA in Chronic Low Back Pain

Degenerative Disc Disease

Enrolment: 404 · Results not recorded

NCT01290367 ↗PHASE2completed

Adult Mesenchymal Precursor Cells (MPCs) With Hyaluronan in Chronic Discogenic Low Back Pain

Degenerative Disc Disease

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23007022 ↗2012Reported benefit

Human mesenchymal precursor cells (Stro-1+) from spinal cord injury patients improve functional recovery and tissue sparing in an acute spinal cord injury rat model.

RatSpinal cord injuryContusionRNU nude (athymic, T-cell deficient)FemaleIntraspinal transplantation as a suspension graft into the injured spinal cordAcutely after contusive spinal cord injury

Model: Acute moderate contusive spinal cord injury with transplantation of a cell suspension graft into the injured cord

Transplanted animals showed statistically significant improvement in functional recovery, tissue sparing and cyst reduction, reaching mean BBB scores of 15 at 8 weeks, with increased 5-HT and CGRP axonal growth around the graft, although retrograde tracing showed no significant difference from cont…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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