Effects of recombinant human granulocyte colony-stimulating factor on central and peripheral T lymphocyte reconstitution after sublethal irradiation in mice.
MouseRadiationBALB/c (H-2d/d)FemaleSubcutaneous100 micrograms/kg (diluted in PBS at 10 micrograms/mL immed…First dose immediately after irradiation (day 0)
Model: Sublethal total body gamma irradiation, single dose of 600 cGy (6 Gy) delivered at 187 cGy/min from a cobalt source (GWXJ80 Theratron)
G-CSF accelerated thymic and peripheral T cell reconstitution after 6 Gy total body irradiation, with higher thymocyte numbers at days 14 to 28, earlier recovery of CD4+CD8+ double-positive thymocytes (day 28 versus day 60 in controls), higher sjTREC frequency at day 30, shortened severe lymphopeni…
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